Lamotrigine-induced Hypersensitivity Syndrome: Case Report

Anticonvulsant hypersensitivity syndrome (AHS) is a life-threatening, idiosyncratic, non-dose related adverse reaction reported to occur with aromatic antiepileptic drugs. We present an 11-year-old girl diagnosed with hypersensitivity syndrome with a fever, rash, lymphadenopathy, and hepatic and pulmonary involvement. Although timely recognition of the signs and symptoms, discontinuation of the drug, supportive care, and close observation are crucial in the management of AHS, the use of systemic corticosteroids and intravenous immunoglobulin seems to be a good option for severe cases with multiorgan involvement as in our patient. We present our case to emphasize once more the importance of close laboratory monitoring and clinical follow-up after starting antiepileptic drugs and also informing the families about the adverse effects of drugs.